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簡(jiǎn)要描述：腫瘤壞死因子受體超家族成員EDAR抗體免 疫 原；KLH conjugated synthetic peptide derived from human EDAR: 141-230/448
產(chǎn)品型號(hào)：GOY-01K1928廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：202產(chǎn)品分類
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腫瘤壞死因子受體超家族成員EDAR抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
腫瘤壞死因子受體超家族成員EDAR抗體 | EDAR | GOY-01K1928 |
商品屬性：
英文名稱: EDAR
中文名:腫瘤壞死因子受體超家族成員EDAR抗體
別 名；Anhidrotic
ectodysplasin receptor 1; DL; Downless (mouse) homolog; Downless homolog;
Downless mouse homolog of; Ectodermal dysplasia receptor; Ectodysplasin 1
anhidrotic receptor; Ectodysplasin A receptor; Ectodysplasin-A receptor; ED 1R;
ED 3; ED 5; ED1R; ED3; ED5; EDA 1R; EDA 3; EDA A1 receptor; EDA A1R; EDA-A1
receptor; EDA1R; EDA3; Edar; EDAR_HUMAN; HRM1; Tumor necrosis factor receptor
superfamily member EDAR.
研究領(lǐng)域；腫瘤 細(xì)胞生物 生長(zhǎng)因子和激素 表觀遺傳學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Rabbit, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；46kDa
細(xì)胞定位；細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human EDAR: 141-230/448
<Extracellular>
亞 型；IgG
純化方法；affinity
purified by Protein A
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The tumor necrosis factor receptor (TNFR)
superfamily represents a growing family of type I transmembrane glycoproteins
that are involved in various cellular functions, including proliferation,
differentiation and programmed cell death. These proteins share homology for
cysteine-rich repeats in the extracellular ligand binding domain and an
intracellular death domain. Members of the TNFR superfamily transmit signals
through protein-protein interactions, and these signals can lead to the
activation of either the caspase and Jun kinase pathways, which promote cell
death, or the NFκB pathway,
which results in cell survival. The ectodermal dysplasia receptor (EDAR)
promotes all three of these pathways and mediates ectodermal differentiation.
EDAR is encoded by the downless gene and is mutated in ectodermal dysplasia
syndromes, which are characterized by impaired hair, teeth and sweat gland
development. Ectodysplasin A (EDA) is a type II membrane protein that is
encoded by the Tabby gene and produces many splice variants, the longest of
which, EDA-A1, serves as the ligand for EDAR. EDA-A2, which differs from
EDA-A1 by the deletion of two amino acids, binds only the X-linked
ectodysplasin-A2 receptor (XEDAR). Both EDAR and XEDAR exhibit homology with
TROY. Function: Receptor for EDA isoform A1, but not for EDA
isoform A2. Mediates the activation of NF-kappa-B and JNK. May promote
caspase-independent cell death. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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