簡要描述:EDEM1蛋白抗體免 疫 原;KLH conjugated Synthesised phosphopeptide derived from human ECT2 around the phosphorylation site of Thr790: 551-657/657
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EDEM1蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
EDEM1蛋白抗體 | EDEM1 | GOY-01K2498 |
商品屬性:
英文名稱: EDEM1
中文名:EDEM1蛋白抗體
別 名;EDEM 1;
EDEM1_HUMAN; EDEM; Endoplasmic reticulum degradation enhancing alpha
mannosidase like protein; ER degradation enhancer, mannosidase alpha like 1; ER
degradation enhancing alpha mannosidase like 1; KIAA0212.
研究領(lǐng)域;細(xì)胞生物 免疫學(xué) 信號轉(zhuǎn)導(dǎo)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Dog, Horse, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;74kDa
細(xì)胞定位;細(xì)胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated Synthesised phosphopeptide derived from human ECT2 around the
phosphorylation site of Thr790: 551-657/657
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件;Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Proteins expressed in the endoplasmic reticulum
(ER) are subjected to a tight quality control. Terminally misfolded proteins
in the endoplasmic reticulum (ER) are retrotranslocated to the cytoplasm and
degraded by proteasomes through a mechanism known as ER-associated
degradation (ERAD). EDEM (ER degradation-enhancing alpha-mannosidase-like)
protein is a type II membrane protein that localizes to the ER and is
directly involved in ERAD. EDEM targets misfolded glycoproteins for
degradation in an N-glycan-dependent manner and extracts misfolded
glycoproteins from the calnexin cycle. The human EDEM gene maps to chromosome
3p. Function: EDEM1 is directly involved in ER associated
degradation (ERAD), and targets misfolded glycoproteins for degradation in an
N glycan dependent manner. It lacks mannosidase activity. EDEM1 belongs to
the glycosyl hydrolase 47 family. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報價,按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動驗(yàn)證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時,也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報價,按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺,能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù),如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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