簡要描述:范可尼貧血相關蛋白M抗體免 疫 原;KLH conjugated synthetic peptide derived from human FANCM: 831-930/2048
產(chǎn)品分類
Product Category相關文章
Related Articles詳細介紹
范可尼貧血相關蛋白M抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
范可尼貧血相關蛋白M抗體 | FANCM | GOY-01K1717 |
商品屬性:
英文名稱: FANCM
中文名:范可尼貧血相關蛋白M抗體
別 名;FAAP250; Fanconi
anemia group M protein; Protein Hef ortholog;
研究領域;細胞生物 發(fā)育生物學 表觀遺傳學
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應;(predicted:
Human, )
產(chǎn)品應用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;232kDa
細胞定位;細胞核
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human FANCM: 831-930/2048
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Fanconi anemia (FA) is an autosomal recessive
disorder characterized by bone marrow failure, birth defects and chromosomal
instability. At the cellular level, FA is characterized by spontaneous
chromosomal breakage and a unique hypersensitivity to DNA cross-linking
agents. The thirteen FA proteins that have been characterized are important
for regulating chromosomal stability and genome surveillance. Eight of these
proteins, namely FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL and FANCM,
comprise the FA core complex, which catalyzes a key reaction in DNA repair:
the monoubiquitination of FANCD2. FANCM (Fanconi anemia, complementation
group M) is a member of the DEAD-box helicase family of proteins and contains
a DEAH helicase domain and a nuclease domain. Localizing to chromatin
fractions, FANCM is phosphorylated in a cell cycle-dependent manner and is
believed to function as an anchor, recruiting the FA core complex to
chromatin. Mutations in the gene encoding FANCM can lead to Fanconi anemia. FANCM is an ATPase required for FANCD2
ubiquitination, a key reaction in DNA repair. It binds to ssDNA but not to
dsDNA. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時,也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺,能為客戶提供各種類型的重組抗體表達服務,包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達,抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務,如動物免疫、動物飼養(yǎng)、抗體修飾服務(如FITC,HRP等的標記)、以及ELISA,WB,IHC,DB等檢測服務。
抗體定制服務:
已注冊商標,主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務,主要面向工業(yè)客戶。
產(chǎn)品咨詢
歡迎您關注我們的微信了解更多信息
電話
微信掃一掃