簡(jiǎn)要描述:白細(xì)胞介素1受體銜接蛋白抗體免 疫 原;KLH conjugated synthetic peptide derived from human TIRAP: 81-221/221
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白細(xì)胞介素1受體銜接蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
白細(xì)胞介素1受體銜接蛋白抗體 | TIRAP | GOY-01K0942 |
商品屬性:
英文名稱: TIRAP
中文名:白細(xì)胞介素1受體銜接蛋白抗體
別 名;Adapter protein
wyatt; MAL; MyD88 adapter like protein; TIR domain containing adapter protein;
Toll interleukin 1 receptor (TIR) domain containing adaptor protein; Toll
interleukin 1 receptor domain containing adapter protein; Toll like receptor
adaptor protein; Wyatt; TIRAP_HUMAN.
研究領(lǐng)域;心血管 細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo)
抗體來(lái)源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Rabbit, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;24kDa
細(xì)胞定位;細(xì)胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human TIRAP: 81-221/221
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The Toll-like receptor (TLR) family in mammals
comprises a family of transmembrane proteins characterized by multiple copies
of leucine rich repeats in the extracellular domain and IL-1 receptor motif
in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal
through adaptor molecules. The TLR family is a phylogenetically conserved
mediator of innate immunity that is essential for microbial recognition. Ten
human homologs of TLRs (TLR1-10) have been described. TIRAP (TIR
domain-containing adaptor protein) is an adaptor protein used by TLR4.
Blocking TIRAP inhibits TLR4-mediated signaling events, including DC
maturation and cytokine production. Adapter involved in TLR2 and TLR4 signaling
pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to
the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine
secretion and the inflammatory response. Positively regulates the production
of TNF-alpha and interleukin-6. |
多克隆抗體制備:
我公司合成抗原,保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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