歡迎來到上海谷研實(shí)業(yè)有限公司網(wǎng)站！
咨詢電話：18321818584歡迎來到上海谷研實(shí)業(yè)有限公司網(wǎng)站！咨詢電話：18321818584
簡要描述：B淋巴細(xì)胞基因1抗體免 疫 原；KLH conjugated synthetic peptide derived from human TLE4: 681-773/773
產(chǎn)品型號：GOY-01K2036廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：270產(chǎn)品分類
Product Category相關(guān)文章
Related Articles詳細(xì)介紹
B淋巴細(xì)胞基因1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
B淋巴細(xì)胞基因1抗體 | TLE4 | GOY-01K2036 |
商品屬性：
英文名稱: TLE4
中文名:B淋巴細(xì)胞基因1抗體
別 名；B lymphocyte gene
1; B lymphocyte gene 1; enhancer of split groucho 4; enhancer of split groucho
4; ESG4; ESG4; KIAA1261; TIM; TIM1; timeless (Drosophila) homolog; TLE4;
transducin-like enhancer of split 4; transducin-like enhancer of split 4;
TLE4_HUMAN.
研究領(lǐng)域；腫瘤 細(xì)胞生物 染色質(zhì)和核信號 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 干細(xì)胞 轉(zhuǎn)錄調(diào)節(jié)因子 細(xì)胞分化
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；84kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human TLE4: 681-773/773
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The Notch signaling pathway controls cellular
interactions important for the specification of a variety of fates in both
invertebrates and vertebrates. Key players in the Notch pathway are the TLE
genes (for transducin-like enhancer of split, also designated ESG for
enhancer of split groucho), which are human homologs of the Drosophila
groucho gene. Groucho is a transcriptional repressor that plays a key role in
neurogenesis, segmentation and sex determination. TLEs associate with
chromatin in live cells and specifically with Histone H3, but not with other
core histones. Expression of the TLE genes, TLE1, TLE2, TLE3 and TLE4,
correlate with immature epithelial cells that are progressing toward a
terminally differentiated state, suggesting a role during epithelial
differentiation. TLE1, TLE2 and TLE3 have elevated expression in cervical
squamous metaplasias and carcinomas, while TLE4 is most highly expressed in
the brain, particularly in the caudate nucleus. TLE1 and TLE4 contain SP and
WD40 domains, through which TLE1 binds AML1 to inhibit AML1-induced
transactivation of the CSF1 receptor. In early stages of cell
differentiation, TLE1 is upregulated, and TLE2 and TLE4 are downregulated. In
later stages, TLE2 and TLE4 are upregulated, and expression of TLE1
decreases. Function: TLE4 (Transducin-like enhancer protein 4) is a
member of the Groucho family of transcriptional corepressors and inhibits the
transcriptional activation mediated by Pax5 and by beta-catenin and TCF
family members in Wnt signaling. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報價，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報價，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
產(chǎn)品咨詢
聯(lián)系人：銷售部
地址：上海市嘉定區(qū)澄瀏公路52號盛創(chuàng)企業(yè)
郵箱：[email protected]
手機(jī)：18321818584 / 15026555973歡迎您關(guān)注我們的微信了解更多信息
掃一掃電話
微信掃一掃