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簡(jiǎn)要描述：Bcl2相關(guān)抗凋亡基因6抗體免 疫 原；KLH conjugated synthetic peptide derived from human BAT3/BAG6: 1042-1132/1132
產(chǎn)品型號(hào)：GOY-01K1620廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：513產(chǎn)品分類
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Bcl2相關(guān)抗凋亡基因6抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
Bcl2相關(guān)抗凋亡基因6抗體 | BAG6 | GOY-01K1620 |
商品屬性：
英文名稱: BAG6
中文名:Bcl2相關(guān)抗凋亡基因6抗體
別 名；family molecular chaperone regulator 6; BAG-6; BAG6; Bag6;
BAG6_HUMAN; BCL2-associated athanogene 6; D6S52E; G3; HLA B associated
transcript 3; HLA-B-associated transcript 3; Large proline-rich protein BAG6;
Protein G3; Protein Scythe.
研究領(lǐng)域；腫瘤 細(xì)胞生物 細(xì)胞凋亡
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；119kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿 細(xì)胞外基質(zhì)
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human BAT3/BAG6: 1042-1132/1132
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Chaperone that plays a key role in various
processes such as apoptosis, insertion of tail-anchored (TA) membrane
proteins to the endoplasmic reticulum membrane and regulation of chromatin.
Acts in part by regulating stability of proteins and their degradation by the
proteasome. Participates in endoplasmic reticulum stress-induced apoptosis
via its interaction with AIFM1/AIF by regulating AIFM1/AIF stability and
preventing its degradation. Also required during spermatogenesis for synaptonemal
complex assembly via its interaction with HSPA2, by inhibiting
polyubiquitination and subsequent proteasomal degradation of HSPA2. Required
for selective ubiquitin-mediated degradation of defective nascent chain
polypeptides by the proteasome. In this context, may play a role in
immuno-proteasomes to generate antigenic peptides via targeted degradation,
thereby playing a role in antigen presentation in immune response. Key
component of the BAG6/BAT3 complex, a cytosolic multiprotein complex involved
in the post-translational delivery of tail-anchored (TA) membrane proteins to
the endoplasmic reticulum membrane. TA membrane proteins, also named type II
transmembrane proteins, contain a single C-terminal transmembrane region.
BAG6/BAT3 acts by facilitating TA membrane proteins capture by ASNA1/TRC40:
it is recruited to ribosomes synthesizing membrane proteins, interacts with
the transmembrane region of newly released TA proteins and transfers them to
ASNA1/TRC40 for targeting to the endoplasmic reticulum membrane. Function: Serine-threonine kinase which transduces
inflammatory and cell-death signals (necroptosis) following death receptors
ligation, activation of pathogen recognition receptors (PRRs), and DNA
damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and
TRAF2 are recruited to the receptor. Ubiquitination by TRAF2 via
'Lys-63'-link chains acts as a critical enhancer of communication with
downstream signal transducers in the mitogen-activated protein kinase pathway
and the NF-kappa-B pathway, which in turn mediate downstream events including
the activation of genes encoding inflammatory molecules. Polyubiquitinated
protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a
critical event for NF-kappa-B activation. Interaction with other cellular
RHIM-containing adapters initiates gene activation and cell death. RIPK1 and
RIPK3 association, in particular, forms a necroptosis-inducing complex. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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