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肌動蛋白樣蛋白6B抗體
產品名稱 | 英文名稱 | 貨號 |
肌動蛋白樣蛋白6B抗體 | BAF53b | GOY-01K1073 |
商品屬性：
英文名稱: BAF53b
中文名:肌動蛋白樣蛋白6B抗體
別 名；53 kDa BRG1
associated factor B; ACL 6B; ACL6B; Actin like 6; Actin like protein 6B; Actin
like protein6B; Actin related protein; Actin related protein Baf53b; actin-like
6B; Actl 6; ACTL 6B; Actl6; ACTL6 B; ACTL6B; Arp Na; ArpN a; ArpN alpha; ArpNa;
ArpNalpha; Baf 53b; ACL6B_HUMAN.
研究領域；神經生物學 干細胞 表觀遺傳學
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；47kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human ACL6B: 301-400/426
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
BAF53b is a member of a family of actin-related
proteins (ARPs), which shares significant sequence identity with conventional
actins. Both actins and ARPs comprise an actin fold, which forms an ATP
binding cleft. BAF53b is a component of the BAF (BRG/brm-associated factor)
complex in mammals, which is functionally related to the SWI/SNF complex in
S. cerevisiae and Drosophila, and is associated with chromatin remodelling to
facilitate transcriptional activation. As neural progenitors exit the cell
cycle, the highly homologous BAF53a subunit of the BAF complex is replaced by
BAF53b. This subunit switch is essential for the transition from from neural
stem cells / progenitors to postmitotic neurons. BAF53b also plays a role in
dendritic outgrowth, during which it is required to recruit the BAF complex
and the dendritic regulator CREST to specific gene promoters. This function
can not be performed by BAF53a. Belongs to the chromatin remodeling brain-specific
BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an
ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling
complex (nBAF complex) and is required for postmitotic neural development and
dendritic outgrowth. During neural development a switch from a stem/progenitor
to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the
cell cycle and become committed to their adult state. The transition from
proliferating neural stem/progenitor cells to post-mitotic neurons requires a
switch in subunit composition of the npBAF and nBAF complexes. As neural
progenitors exit mitosis and differentiate into neurons, npBAF complexes
which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous
alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in
neuron-specific complexes (nBAF). The npBAF complex is essential for the
self-renewal/proliferative capacity of the multipotent neural stem cells. The
nBAF complex along with CREST plays a role regulating the activity of genes
essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of
the nBAF complex but is required for targeting the complex and CREST to the
promoter of genes essential for dendritic growth (By similarity). |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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