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簡(jiǎn)要描述：G蛋白偶聯(lián)受體ARHGEF18抗體免 疫 原；KLH conjugated synthetic peptide derived from human ARHGEF18/p114RhoGEF: 501-600/1173
產(chǎn)品型號(hào)：GOY-01K0663廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：525產(chǎn)品分類
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G蛋白偶聯(lián)受體ARHGEF18抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
G蛋白偶聯(lián)受體ARHGEF18抗體 | ARHGEF18 | GOY-01K0663 |
商品屬性：
英文名稱: ARHGEF18
中文名:G蛋白偶聯(lián)受體ARHGEF18抗體
別 名；p114RhoGEF; 114
kDa Rho specific guanine nucleotide exchange factor; ARHGEF 18; ARHGEF18;
KIAA0521; MGC15913; p114 Rho GEF; p114-Rho-GEF; Rho specific guanine nucleotide
exchange factor p114; Rho-specific guanine nucleotide exchange factor p114;
Rho/Rac guanine nucleotide exchange factor (GEF) 18; Rho/Rac guanine nucleotide
exchange factor 18; SA RhoGEF; Septin associated RhoGEF; ARHGI_HUMAN.
研究領(lǐng)域；細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) G蛋白偶聯(lián)受體 G蛋白信號(hào)
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；131kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human ARHGEF18/p114RhoGEF:
501-600/1173
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Rho GTPases are GTP binding proteins that regulate
a wide spectrum of cellular functions. These cellular processes include
cytoskeletal rearrangements, gene transcription, cell growth and motility.
Activation of Rho GTPases is under the direct control of guanine nucleotide
exchange factors (GEFs). The protein encoded by this gene is a guanine
nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family
members share a common feature, a Dbl (DH) homology domain followed by a
pleckstrin (PH) homology domain. Alternatively spliced transcript variants
encoding different isoforms have been identified. [provided by RefSeq, Oct
2008]. Function: Rho GTPases are GTP binding proteins that regulate
a wide spectrum of cellular functions. These cellular processes include
cytoskeletal rearrangements, gene transcription, cell growth and motility.
Activation of Rho GTPases is under the direct control of guanine nucleotide
exchange factors (GEFs). p114RgoGEF cts as guanine nucleotide exchange factor
(GEF) for RhoA GTPases. It may play a role in actin cytoskeleton
reorganization in different tissues since its activation induces formation of
actin stress fibers. It also act as a GEF for RAC1, inducing production of
reactive oxygen species (ROS), but does not act as a GEF for CDC42. The G
protein beta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as
activators, explaining the integrated effects of LPA and other G-protein
coupled receptor agonists on actin stress fiber formation, cell shape change
and ROS production. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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