簡要描述:β淀粉樣蛋白胞內(nèi)結(jié)構(gòu)域相關(guān)蛋白1抗體免 疫 原;KLH conjugated synthetic peptide derived from human ANKS1B/AIDA1: 851-1000/1248
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β淀粉樣蛋白胞內(nèi)結(jié)構(gòu)域相關(guān)蛋白1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
β淀粉樣蛋白胞內(nèi)結(jié)構(gòu)域相關(guān)蛋白1抗體 | ANKS1B | GOY-01K1032 |
商品屬性:
英文名稱: ANKS1B
中文名:β淀粉樣蛋白胞內(nèi)結(jié)構(gòu)域相關(guān)蛋白1抗體
別 名;AIDA 1; AIDA-1;
Amyloid-beta protein intracellular domain-associated protein 1; Anks1b; Ankyrin
repeat and sterile alpha motif domain-containing protein 1B; ANS1B_HUMAN;
E2A-PBX1-associated protein; EB-1.
研究領(lǐng)域;細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) Alzheimer's
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;138kDa
細(xì)胞定位;細(xì)胞核 細(xì)胞漿 細(xì)胞膜 細(xì)胞外基質(zhì)
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human ANKS1B/AIDA1: 851-1000/1248
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng);This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The β-Amyloid
protein precursor (AbPP) is a widely expressed transmembrane protein that is
processed into the b-Amyloid (Ab) peptide, which accumulates in insoluble
plaques in the brain of Alzheimer’s disease patients
and AbPP intracellular domain (AID). AID may function as a pro-apoptotic
peptide, a regulator of calcium homeostasis and a molecule involved in
transcriptional regulation. The AID associated protein 1 (AIDA-1) is highly
expressed in the brain and is regulated by AbPP. It interacts with AbPP to
play a role in brain development. AIDA-1 also interacts with coilin in Cajal
bodies to regulate pre-mRNA splicing. Isoform 2 may participate in the regulation of
nucleoplasmic coilin protein interactions in neuronal and transformed cells. Isoform 3 can regulate global protein synthesis by
altering nucleolar numbers. Isoform 4 may play a role as a modulator of APP
processing. Overexpression can down-regulate APP processing. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價(jià)達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行,我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中,與客戶互動(dòng)驗(yàn)證,確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí),也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià),按節(jié)點(diǎn)收費(fèi),為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái),能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù),如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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