簡要描述:β淀粉樣前體蛋白結(jié)合蛋白2抗體免 疫 原;KLH conjugated synthetic peptide derived from human APBA2: 351-450/749
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β淀粉樣前體蛋白結(jié)合蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
β淀粉樣前體蛋白結(jié)合蛋白2抗體 | APBA2 | GOY-01K1087 |
商品屬性:
英文名稱: APBA2
中文名:β淀粉樣前體蛋白結(jié)合蛋白2抗體
別 名;Adapter protein
X11beta; Amyloid beta A4 precursor protein-binding family A member 2; X11β; APBA2_HUMAN; D15S1518E; HsT16821; LIN 10; Mint 2; Mint-2;
Neuron-specific X11L protein; Neuronal Munc18-1-interacting protein 2;
Phosphotyrosine binding/interacting domain (PTB) bearing protein; X11 beta;
X11l.
研究領(lǐng)域;細(xì)胞生物 神經(jīng)生物學(xué) Alzheimer's
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Chicken, Dog, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;82kDa
細(xì)胞定位;細(xì)胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human APBA2: 351-450/749
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The Beta-Amyloid precursor protein (Beta-APP) is a
major constituent of the amyloid deposits in patients with Alzheimer’s disease. The Beta-Amyloid precursor is known to
interact with several proteins, including X11 and the G heterotrimetric
protein APP-BP1. The neuronal, transmembrane protein X11 is known to bind to
the ∫-Amyloid precursor protein via a phosphotyrosine
binding (PTB) domain, reducing the secretion of cellular Beta-APP and slowing
Beta-APP processing pathways. X11 binds specifically to the YENPTY motif,
which is involved in the internalization of Beta-APP. Multiple splice
varitents of X11 have been identified, including X11 Alpha (also designated
Mint 1), X11 Beta (Mint 2) and X11 Gamma(Mint 3). Putative function in synaptic vesicle exocytosis
by binding to STXBP1, an essential component of the synaptic vesicle
exocytotic machinery. May modulate processing of the beta-amyloid precursor
protein (APP) and hence formation of beta-APP. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時,也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺,能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù),如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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