歡迎來(lái)到上海谷研實(shí)業(yè)有限公司網(wǎng)站！
咨詢電話：18321818584歡迎來(lái)到上海谷研實(shí)業(yè)有限公司網(wǎng)站！咨詢電話：18321818584
簡(jiǎn)要描述：免疫調(diào)節(jié)蛋白AIRE抗體免 疫 原；KLH conjugated synthetic peptide derived from human PGA1/AIRE: 51-150/545
產(chǎn)品型號(hào)：GOY-01K2337廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：540產(chǎn)品分類
Product Category相關(guān)文章
Related Articles詳細(xì)介紹
免疫調(diào)節(jié)蛋白AIRE抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
免疫調(diào)節(jié)蛋白AIRE抗體 | AIRE | GOY-01K2337 |
商品屬性：
英文名稱: AIRE
中文名:免疫調(diào)節(jié)蛋白AIRE抗體
別 名；AIRE-1; AIRE;
AIRE_HUMAN; AIRE1; APECED; APECED protein; APS1; APSI; Autoimmune
polyendocrinopathy candidiasis ectodermal dystrophy protein; Autoimmune regulator;
Autoimmune regulator protein; PGA1.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 鋅指蛋白
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Horse, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；58kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human PGA1/AIRE: 51-150/545
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The autoimmune regulator gene, which is defective
in the hereditary auto-immune disease APECED, encodes the transcriptional
activator AIRE. AIRE is expressed in the medullary epithelial cells and
monocyte-dendritic cells of the thymus, with lower expression in the spleen,
fetal liver and lymph nodes. In adult tissue, AIRE expression in the thymus
is confined to the medulla and the cortico-medullary junction, where it is
modulated by thymocytes undergoing negative selection. At the cellular level,
AIRE is located in microtubular structures of the cyto-skeleton and in
discrete nuclear dots resembling ND10 nuclear bodies. AIRE is induced by
developing early thymocytes and is associated with the correct establishment
of a regular thymic environment. AIRE regulates thymic architecture via
transcriptional control of downstream target genes. AIRE mutations in APECED
patients may affect thymic T cell selection and the formation of
self-tolerance. Transcriptional regulator that binds to DNA as a
dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an
A/T-rich environment; the preferred motif is a tandem repeat of 5'-.
ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes (By
similarity). Binds to chromatin and interacts selectively with histone H3
that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not
methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that
are important for the epigenetic regulation of gene expression. Functions as
a transcriptional activator and promotes the expression of otherwise
tissue-specific self-antigens in the thymus, which is important for self
tolerance and the avoidance of autoimmune reactions. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
產(chǎn)品咨詢
聯(lián)系人：銷售部
地址：上海市嘉定區(qū)澄瀏公路52號(hào)盛創(chuàng)企業(yè)
郵箱：[email protected]
手機(jī)：18321818584 / 15026555973歡迎您關(guān)注我們的微信了解更多信息
掃一掃電話
微信掃一掃